منابع مشابه
piRNA cluster database: a web resource for piRNA producing loci
Piwi proteins and their guiding small RNAs, termed Piwi-interacting (pi-) RNAs, are essential for silencing of transposons in the germline of animals. A substantial fraction of piRNAs originates from genomic loci termed piRNA clusters and sequences encoded in these piRNA clusters determine putative targets for the Piwi/piRNA system. In the past decade, studies of piRNA transcriptomes in differe...
متن کاملAlexei A . Aravin , Implicate MILI in Transposon Control Developmentally Regulated piRNA Clusters
www.sciencemag.org (this information is current as of July 2, 2009 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/316/5825/744 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/1142612/DC1 can be found at: Sup...
متن کاملSomatic piRNA biogenesis.
Piwi-interacting RNAs (piRNAs) protect animal germ cells from transposons and other selfish genetic elements. Of the three types of animal small-silencing RNAs—smallinterfering RNAs (siRNAs), microRNAs (miRNAs), and piRNAs—piRNAs are the least well understood, because we lack good tools for studying how they are made and how they function. Brennecke et al have now established a method for trigg...
متن کاملpiRNA Rules of Engagement.
piRNAs are known to silence transposable elements, but not all piRNAs match transposon sequences. Recent studies from Shen et al. (2018) and Zhang et al. (2018) identify rules for piRNA target recognition in Caenorhabditis elegans. Permissive pairing rules allow targeting of essentially all germline mRNAs, while protective mechanisms prevent silencing self-genes.
متن کاملA piRNA to Remember
In this issue of Cell, Rajasethupathy et al. report a surprising role for piRNAs, previously thought to act mainly in the animal germline to silence transposons, in transcriptional regulation of plasticity-related genes in the central nervous system of the sea slug Aplysia californica. The findings expand the functions of small RNAs and have important implications for our understanding of how t...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2012
ISSN: 1471-003X,1471-0048
DOI: 10.1038/nrn3268